TECHNOLOGY OVERVIEW

NON INVASIVE, TARGETED EXTRACTION


Micro-needle devices have been used for drug delivery and vaccine delivery for many years. Instead of using micro-needle devices to deliver a product into the skin, we use them to extract biomarkers from within the skin (epidermis and dermis).

Our devices are engineered to maximize biomarker extraction while minimizing pain. They are also chemically funtionalized with specific probes which can then extract specific mRNA sequences when the device is applied to the skin.

Our targeted extraction approach ensures maximal extraction efficiency and gives optimal signal to noise ratio. Our Whole Transcriptome Extraction product has been successfully tested in human subjects:

  • Safety demonstrated in 36 patients
  • Analytical validation vs. biopsy in human subjects established (29 subjects)
  • Excellent correlation vs. biopsy demonstrated

EASY WORKLOW

qPCR NGS workflow


RESEARCH APPLICATIONS

CURRENT METHODS HAVE MANY SHORTCOMINGS


Tape stripping (repeated application of adhesive tape to remove cells and tissue) and skin swabbing are sampling methods that are frequently used today for research applications in dermatology but researchers are not satisfied with these approaches.

Tape stripping is invasive and not reproducible as results vary widely depending on technique of the operator. Skin swabbing is superficial and does not access biomarkers in the skin.

THE MiNDERA SOLUTION

Our targeted extraction approach results in more sensitive, more reproducible and more informative sampling. Also because of its non-invasiveness our technology will enable researchers to conduct larger scale and more informative studies.

Our first product is our Whole Transcriptome Extraction device, which enables complete and non-invasive gene expression profiles from the skin. This product has already attracted the interest of large customers with several collaborations with global Pharma and Skin Care leaders. We are currently seeking partnerships with BioPharma companies who would be interested in using our technology, which we believe can greatly accelerate their research and clinical development efforts by enabling clinical development teams to acquire many more data points more frequently because of the non-invasiveness and cost effectiveness of our technology.

If you are interested in finding out more, please contact us at info@minderadx.com

 

CLINICAL DIAGNOSTICS

 

Beyond Research applications, MiNDERA will develop a portfolio of highly innovative and non-invasive diagnostic tests targeting skin diseases (oncology, inflammatory skin diseases).

KEY BENEFITS

MiNDERA Technology Benefits:

  • No pain or scar, can be used by researchers under IRB approval

  • Cost effective vs. biopsy

  • Feeds into established analytical lab workflows

PUBLICATIONS

MiNDERA SID 2017 Poster: Non-invasive transcriptome extraction from the skin using MiNDERA microneedle technology - Sherrif Ibrahim, Bradford J. Taft, Shreya Pramanick, Thejus Mannath, Philippe Nore, & Tobin J. Dickerson

 
Disclaimer: The products described on this website are for Research Use Only.

MiNDERA Corporation

info@minderadx.com

Tel: (1) 650.491.9643

Our Policies

© Copyright 2015, MiNDERA Corporation